2-Fluorophenylboronic acid → HCID 57894217, compound

HRID 1822321Notes

Reaction equation

HRID 1822321 reaction equation
C([O:3][C:4](=[O:34])[CH2:5][CH2:6][C:7]1[CH:12]=[CH:11][C:10]([O:13][C:14]2[CH:19]=[C:18]([CH3:20])[CH:17]=[C:16]([O:21][C:22]3[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][C:23]=3Br)[CH:15]=2)=[CH:9][C:8]=1[CH3:33])C.[F:35][C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][C:37]=1B(O)O>>[F:35][C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][C:37]=1[C:23]1[CH:24]=[C:25]([C:28]([F:29])([F:31])[F:30])[CH:26]=[CH:27][C:22]=1[O:21][C:16]1[CH:15]=[C:14]([CH:19]=[C:18]([CH3:20])[CH:17]=1)[O:13][C:10]1[CH:11]=[CH:12][C:7]([CH2:6][CH2:5][C:4]([OH:3])=[O:34])=[C:8]([CH3:33])[CH:9]=1

Participants

3

Reactant 2

HCID 27343542-Fluorophenylboronic acidHCID 57894173HCID 57894173, compound

Product 1

HCID 57894217HCID 57894217, compound

Procedure

The tile compound is prepared by reacting 3-{4-[3-(2-bromo-4-trifluoromethyl-phenoxy)-5-methyl-phenoxy]-2-methyl-phenyl}-propionic acid ethyl ester with 2-fluorobenzene boronic acid as in Example 38 to afford 0.216 g (88%). 1H NMR (400 MHz, CDCl3); HRMS (ES+) m/z exact mass calculated for C30H25O4F4 525.1689, found 525.1675.

Workup

  1. customThe tile compound is prepared
  2. customto afford 0.216 g (88%)

Sources & evidence

ORD record
ord-72dda68fb9fb4da3b87735c941a82722
Source dataset
uspto-grants-2009_10
Patent number
US07608639B2

Reaction notes

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