3-[4-(3-Bromo-5-methyl-phenoxy)-2-methyl-phenyl]-propionic acid methyl ester → 3-{2-Methyl-4-[3-methyl-5-(2-phenoxy-5-trifluoromethyl-phenoxy)-phenoxy]-phenyl}-propionic acid
Reaction equation
[O:1]([C:8]1[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][C:9]=1[OH:18])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C[O:20][C:21](=[O:40])[CH2:22][CH2:23][C:24]1[CH:29]=[CH:28][C:27]([O:30][C:31]2[CH:36]=[C:35]([CH3:37])[CH:34]=[C:33](Br)[CH:32]=2)=[CH:26][C:25]=1[CH3:39]>>[CH3:39][C:25]1[CH:26]=[C:27]([O:30][C:31]2[CH:32]=[C:33]([O:18][C:9]3[CH:10]=[C:11]([C:14]([F:15])([F:16])[F:17])[CH:12]=[CH:13][C:8]=3[O:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[CH:34]=[C:35]([CH3:37])[CH:36]=2)[CH:28]=[CH:29][C:24]=1[CH2:23][CH2:22][C:21]([OH:40])=[O:20]Participants
3
Procedure
The compound of 2-phenoxy-5-trifluoromethyl-phenol is reacted with 3-[4-(3-bromo-5-methyl-phenoxy)-2-methyl-phenyl]-propionic acid methyl ester as in Example 18 to afford 0.262 g (34%) of the title compound. 1H NMR (400 MHz, CDCl3); MS (ES+) m/z mass calculated for C30H25O5F3 522, found 523 (M+1, 100%).
Sources & evidence
- ORD record
- ord-585e92947bf34afe8a1d80bdd076a792
- Source dataset
- uspto-grants-2009_10
- Patent number
- US07608639B2
Reaction notes
Loading…