HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-[4-(3-Bromo-5-methyl-phenoxy)-2-methyl-phenyl]-propionic acid methyl ester → 3-{2-Methyl-4-[3-methyl-5-(2-oxo-3-phenoxy-5-trifluoromethyl-2H-pyridin-1-yl)-phenoxy]-phenyl}-propionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-[4-(3-Bromo-5-methyl-phenoxy)-2-methyl-phenyl]-propionic acid methyl ester | HCID 57894212 | — |
| Reactant | 3-Phenoxy-5-trifluoromethyl-pyridin-2-ol | HCID 178517753 | — |
| Product | 3-{2-Methyl-4-[3-methyl-5-(2-oxo-3-phenoxy-5-trifluoromethyl-2H-pyridin-1-yl)-phenoxy]-phenyl}-propionic acid | HCID 69070530 | — |
Reaction Steps
The title compound is prepared according to Example 8 by using 3-phenoxy-5-trifluoromethyl-pyridin-2-ol and 3-[4-(3-bromo-5-methyl-phenoxy)-2-methyl-phenyl]-propionic acid methyl ester to afford 37 mg (7%). 1H NMR (400 MHz, CDCl3); MS (ES+) m/z mass calcd for C29H24O5NF3 523, found 524 (M+1, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07608639B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-f5e937aa8d2947ebadc091b2ed1d5e38 |
| Source note | uspto-grants-2009_10 |