2-(Tributylstannyl)pyridine → HCID 57894160, compound

HRID 1822356Notes

Reaction equation

HRID 1822356 reaction equation
C([Sn](CCCC)(CCCC)[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][N:7]=1)CCC.C[O:21][C:22](=[O:51])[CH2:23][CH2:24][C:25]1[CH:30]=[CH:29][C:28]([O:31][C:32]2[CH:37]=[CH:36][CH:35]=[C:34]([O:38][C:39]3[CH:44]=[CH:43][C:42]([C:45]([F:48])([F:47])[F:46])=[CH:41][C:40]=3Br)[CH:33]=2)=[CH:27][C:26]=1[CH3:50]>>[CH3:50][C:26]1[CH:27]=[C:28]([O:31][C:32]2[CH:37]=[CH:36][CH:35]=[C:34]([O:38][C:39]3[CH:44]=[CH:43][C:42]([C:45]([F:47])([F:48])[F:46])=[CH:41][C:40]=3[C:6]3[CH:11]=[CH:10][CH:9]=[CH:8][N:7]=3)[CH:33]=2)[CH:29]=[CH:30][C:25]=1[CH2:24][CH2:23][C:22]([OH:51])=[O:21]

Participants

3

Reactant 2

HCID 6077842-(Tributylstannyl)pyridineHCID 57894211HCID 57894211, compound

Product 1

HCID 57894160HCID 57894160, compound

Procedure

The title compound is prepared according to Example 89 by using 2-tributylstannyl pyridine and 3-{4-[3-(2-bromo-4-trifluoromethyl-phenoxy)-phenoxy]-2-methyl-phenyl}-propionic acid methyl ester to afford about 29 mg (14%). 1H NMR (400 MHz, CDCl3); MS (ES+) m/z mass calcd for C28H22NO4F3 493, found 494 (M+1, 100%).

Workup

  1. customto afford about 29 mg (14%)

Sources & evidence

ORD record
ord-3eff1eac58314ca385d18b7243ac53c6
Source dataset
uspto-grants-2009_10
Patent number
US07608639B2

Reaction notes

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