3-Pyridinylboronic acid → HCID 57894188, compound

HRID 1822357Notes

Reaction equation

HRID 1822357 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3](B(O)O)[CH:2]=1.C[O:11][C:12](=[O:41])[CH2:13][CH2:14][C:15]1[CH:20]=[CH:19][C:18]([O:21][C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([O:28][C:29]3[CH:34]=[CH:33][C:32]([C:35]([F:38])([F:37])[F:36])=[CH:31][C:30]=3Br)[CH:23]=2)=[CH:17][C:16]=1[CH3:40]>>[CH3:40][C:16]1[CH:17]=[C:18]([O:21][C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([O:28][C:29]3[CH:34]=[CH:33][C:32]([C:35]([F:37])([F:38])[F:36])=[CH:31][C:30]=3[C:3]3[CH:2]=[N:1][CH:6]=[CH:5][CH:4]=3)[CH:23]=2)[CH:19]=[CH:20][C:15]=1[CH2:14][CH2:13][C:12]([OH:41])=[O:11]

Participants

3

Reactant 2

HCID 27343783-Pyridinylboronic acidHCID 57894211HCID 57894211, compound

Product 1

HCID 57894188HCID 57894188, compound

Procedure

The title compound is prepared according to Example 89 by using 3-pyridyl boronic acid and 3-{4-[3-(2-bromo-4-trifluoromethyl-phenoxy)-phenoxy]-2-methyl-phenyl}-propionic acid methyl ester to afford about 277 mg (88%). 1H NMR (400 MHz, CDCl3); MS (ES+) m/z mass calcd for C28H22NO4F3 493, found 494 (M+1, 100%).

Workup

  1. customto afford about 277 mg (88%)

Sources & evidence

ORD record
ord-023fe2cc160f4b1890dd83a1e85c830e
Source dataset
uspto-grants-2009_10
Patent number
US07608639B2

Reaction notes

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