2-Phenoxy-3-trifluoromethyl-phenol → 3-{2-Methyl-4-[3-(2-phenoxy-3-trifluoromethyl-phenoxy)-phenoxy]-phenyl}-propionic acid

HRID 1822359Notes

Reaction equation

HRID 1822359 reaction equation
[O:1]([C:8]1[C:13]([C:14]([F:17])([F:16])[F:15])=[CH:12][CH:11]=[CH:10][C:9]=1[OH:18])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C[O:20][C:21](=[O:39])[CH2:22][CH2:23][C:24]1[CH:29]=[CH:28][C:27]([O:30][C:31]2[CH:36]=[CH:35][CH:34]=[C:33](Br)[CH:32]=2)=[CH:26][C:25]=1[CH3:38]>>[CH3:38][C:25]1[CH:26]=[C:27]([O:30][C:31]2[CH:36]=[CH:35][CH:34]=[C:33]([O:18][C:9]3[CH:10]=[CH:11][CH:12]=[C:13]([C:14]([F:15])([F:16])[F:17])[C:8]=3[O:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)[CH:32]=2)[CH:28]=[CH:29][C:24]=1[CH2:23][CH2:22][C:21]([OH:39])=[O:20]

Participants

3

Reactant 2

HCID 541728522-Phenoxy-3-trifluoromethyl-phenolHCID 578941923-[4-(3-Bromo-phenoxy)-2-methyl-phenyl]-propionic acid methyl ester

Product 1

HCID 578941623-{2-Methyl-4-[3-(2-phenoxy-3-trifluoromethyl-phenoxy)-phenoxy]-phenyl}-propionic acid

Procedure

The title compound is prepared according to Example 85 by using 2-phenoxy-3-trifluoromethyl-phenol and 3-[4-(3-bromo-phenoxy)-2-methyl-phenyl]-propionic acid methyl ester to afford about 111 mg (6%). 1H NMR (400 MHz, CDCl3); MS (ES+) m/z mass calcd for C29H23O5F3 508, found 509 (M+1, 100%).

Workup

  1. customto afford about 111 mg (6%)

Sources & evidence

ORD record
ord-c47007f9f10f4ef89f47765b22976aa2
Source dataset
uspto-grants-2009_10
Patent number
US07608639B2

Reaction notes

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