2-(Trifluoromethoxy)phenylboronic Acid (contains varying amounts of Anhydride) → HCID 57894184, compound

HRID 1822362Notes

Reaction equation

HRID 1822362 reaction equation
[F:1][C:2]([F:14])([F:13])[O:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1B(O)O.C[O:16][C:17](=[O:46])[CH2:18][CH2:19][C:20]1[CH:25]=[CH:24][C:23]([O:26][C:27]2[CH:32]=[CH:31][CH:30]=[C:29]([O:33][C:34]3[CH:39]=[CH:38][C:37]([C:40]([F:43])([F:42])[F:41])=[CH:36][C:35]=3Br)[CH:28]=2)=[CH:22][C:21]=1[CH3:45]>>[CH3:45][C:21]1[CH:22]=[C:23]([O:26][C:27]2[CH:32]=[CH:31][CH:30]=[C:29]([O:33][C:34]3[CH:39]=[CH:38][C:37]([C:40]([F:42])([F:43])[F:41])=[CH:36][C:35]=3[C:5]3[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=3[O:3][C:2]([F:14])([F:13])[F:1])[CH:28]=2)[CH:24]=[CH:25][C:20]=1[CH2:19][CH2:18][C:17]([OH:46])=[O:16]

Participants

3

Reactant 2

HCID 27772042-(Trifluoromethoxy)phenylboronic Acid (contains varying amounts of Anhydride)HCID 57894211HCID 57894211, compound

Product 1

HCID 57894184HCID 57894184, compound

Procedure

The title compound is prepared according to Example 89 by using 2-trifluoromethoxyphenyl boronic acid and 3-{4-[3-(2-bromo-4-trifluoromethyl-phenoxy)-phenoxy]-2-methyl-phenyl}-propionic acid methyl ester to afford about 94 mg (58%). 1H NMR (400 MHz, CDCl3); MS (ES+) m/z mass calcd for C30H22O5F6 576, found 577 (M+1, 100%).

Workup

  1. customto afford about 94 mg (58%)

Sources & evidence

ORD record
ord-5dff14c2ae454063b4b4dd89ee7bcbdd
Source dataset
uspto-grants-2009_10
Patent number
US07608639B2

Reaction notes

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