2-Methoxyphenylboronic acid → HCID 57894191, compound

HRID 1822363Notes

Reaction equation

HRID 1822363 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1B(O)O.C[O:13][C:14](=[O:43])[CH2:15][CH2:16][C:17]1[CH:22]=[CH:21][C:20]([O:23][C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([O:30][C:31]3[CH:36]=[CH:35][C:34]([C:37]([F:40])([F:39])[F:38])=[CH:33][C:32]=3Br)[CH:25]=2)=[CH:19][C:18]=1[CH3:42]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:32]1[CH:33]=[C:34]([C:37]([F:40])([F:39])[F:38])[CH:35]=[CH:36][C:31]=1[O:30][C:26]1[CH:25]=[C:24]([CH:29]=[CH:28][CH:27]=1)[O:23][C:20]1[CH:21]=[CH:22][C:17]([CH2:16][CH2:15][C:14]([OH:43])=[O:13])=[C:18]([CH3:42])[CH:19]=1

Participants

3

Reactant 2

HCID 27339582-Methoxyphenylboronic acidHCID 57894211HCID 57894211, compound

Product 1

HCID 57894191HCID 57894191, compound

Procedure

The title compound is prepared according to Example 89 by using 2-methoxyphenyl boronic acid and 3-{4-[3-(2-bromo-4-trifluoromethyl-phenoxy)-phenoxy]-2-methyl-phenyl}-propionic acid methyl ester to afford about 102 mg (64%). 1H NMR (400 MHz, CDCl3); MS (ES+) m/z mass calcd for C30H25O5F3 522, found 523 (M+1, 100%).

Workup

  1. customto afford about 102 mg (64%)

Sources & evidence

ORD record
ord-d0f86aaebb16492eb8c9fd41fba98051
Source dataset
uspto-grants-2009_10
Patent number
US07608639B2

Reaction notes

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