2-(Trifluoromethyl)benzeneboronic acid → HCID 57894230, compound

HRID 1822364Notes

Reaction equation

HRID 1822364 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1C=CC=C[C:4]=1B(O)O.C[O:15][C:16](=[O:45])[CH2:17][CH2:18][C:19]1[CH:24]=[CH:23][C:22]([O:25][C:26]2[CH:31]=[CH:30][CH:29]=[C:28]([O:32][C:33]3[CH:38]=[CH:37][C:36]([C:39]([F:42])([F:41])[F:40])=[CH:35][C:34]=3Br)[CH:27]=2)=[CH:21][C:20]=1[CH3:44]>>[F:1][C:2]([F:13])([F:12])[C:3]1[CH:37]=[CH:38][C:33]([O:32][C:28]2[CH:27]=[C:26]([CH:31]=[CH:30][CH:29]=2)[O:25][C:22]2[CH:23]=[CH:24][C:19]([CH2:18][CH2:17][C:16]([OH:15])=[O:45])=[C:20]([CH3:44])[CH:21]=2)=[C:34]([C:35]2[CH:19]=[CH:18][CH:17]=[CH:16][C:36]=2[C:39]([F:41])([F:42])[F:40])[CH:4]=1

Participants

3

Reactant 2

HCID 27343872-(Trifluoromethyl)benzeneboronic acidHCID 57894211HCID 57894211, compound

Product 1

HCID 57894230HCID 57894230, compound

Procedure

The title compound is prepared according to Example 89 by using 2-trifluoromethylphenyl boronic acid and 3-{4-[3-(2-bromo-4-trifluoromethyl-phenoxy)-phenoxy]-2-methyl-phenyl}-propionic acid methyl ester to afford about 108 mg (68%). 1H NMR (400 MHz, CDCl3); MS (ES+) m/z mass calcd for C30H22O4F6 560, found 561 (M+1,100%).

Workup

  1. customto afford about 108 mg (68%)

Sources & evidence

ORD record
ord-2a21c14141a148269181c80ee40a0aa6
Source dataset
uspto-grants-2009_10
Patent number
US07608639B2

Reaction notes

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