2-Chlorophenylboronic acid → HCID 57894194, compound

HRID 1822365Notes

Reaction equation

HRID 1822365 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1B(O)O.C[O:12][C:13](=[O:42])[CH2:14][CH2:15][C:16]1[CH:21]=[CH:20][C:19]([O:22][C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([O:29][C:30]3[CH:35]=[CH:34][C:33]([C:36]([F:39])([F:38])[F:37])=[CH:32][C:31]=3Br)[CH:24]=2)=[CH:18][C:17]=1[CH3:41]>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:31]1[CH:32]=[C:33]([C:36]([F:39])([F:38])[F:37])[CH:34]=[CH:35][C:30]=1[O:29][C:25]1[CH:24]=[C:23]([CH:28]=[CH:27][CH:26]=1)[O:22][C:19]1[CH:20]=[CH:21][C:16]([CH2:15][CH2:14][C:13]([OH:42])=[O:12])=[C:17]([CH3:41])[CH:18]=1

Participants

3

Reactant 2

HCID 27343222-Chlorophenylboronic acidHCID 57894211HCID 57894211, compound

Product 1

HCID 57894194HCID 57894194, compound

Procedure

The title compound is prepared according to Example 89 by using 2-chlorophenyl boronic acid and 3-{4-[3-(2-bromo-4-trifluoromethyl-phenoxy)-phenoxy]-2-methyl-phenyl}-propionic acid methyl ester to afford about 122 mg (66%). 1H NMR (400 MHz, CDCl3); MS (ES+) m/z mass calcd for C29H22O4F3Cl 526, found 527 and 529 (M+1 and M+3,100%).

Workup

  1. customto afford about 122 mg (66%)

Sources & evidence

ORD record
ord-68ca1079589b452fb1a3ab119bf1e251
Source dataset
uspto-grants-2009_10
Patent number
US07608639B2

Reaction notes

Loading…