4-Fluorophenylboronic acid → HCID 57894207, compound

HRID 1822366Notes

Reaction equation

HRID 1822366 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5](B(O)O)=[CH:4][CH:3]=1.C[O:12][C:13](=[O:42])[CH2:14][CH2:15][C:16]1[CH:21]=[CH:20][C:19]([O:22][C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([O:29][C:30]3[CH:35]=[CH:34][C:33]([C:36]([F:39])([F:38])[F:37])=[CH:32][C:31]=3Br)[CH:24]=2)=[CH:18][C:17]=1[CH3:41]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:31]2[CH:32]=[C:33]([C:36]([F:39])([F:38])[F:37])[CH:34]=[CH:35][C:30]=2[O:29][C:25]2[CH:24]=[C:23]([CH:28]=[CH:27][CH:26]=2)[O:22][C:19]2[CH:20]=[CH:21][C:16]([CH2:15][CH2:14][C:13]([OH:42])=[O:12])=[C:17]([CH3:41])[CH:18]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 2856454-Fluorophenylboronic acidHCID 57894211HCID 57894211, compound

Product 1

HCID 57894207HCID 57894207, compound

Procedure

The title compound is prepared according to Example 89 by using 4-fluorophenyl boronic acid and 3-{4-[3-(2-bromo-4-trifluoromethyl-phenoxy)-phenoxy]-2-methyl-phenyl}-propionic acid methyl ester to afford about 129 mg (60%). 1H NMR (400 MHz, CDCl3); MS (ES+) m/z mass calcd for C29H22O4F4 510, found 511 (M+1, 100%).

Workup

  1. customto afford about 129 mg (60%)

Sources & evidence

ORD record
ord-893bf821cc144046892193583be5e980
Source dataset
uspto-grants-2009_10
Patent number
US07608639B2

Reaction notes

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