3-(Trifluoromethyl)phenylboronic acid → HCID 57894144, compound

HRID 1822368Notes

Reaction equation

HRID 1822368 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:4]=[C:5](B(O)O)[CH:6]=[CH:7][CH:8]=1.C[O:15][C:16](=[O:45])[CH2:17][CH2:18][C:19]1[CH:24]=[CH:23][C:22]([O:25][C:26]2[CH:31]=[CH:30][CH:29]=[C:28]([O:32]C3C=CC(C(F)(F)F)=CC=3Br)[CH:27]=2)=[CH:21][C:20]=1[CH3:44]>>[F:1][C:2]([F:13])([F:12])[C:3]1[CH:8]=[CH:7][C:6]([O:32][C:28]2[CH:27]=[C:26]([CH:31]=[CH:30][CH:29]=2)[O:25][C:22]2[CH:23]=[CH:24][C:19]([CH2:18][CH2:17][C:16]([OH:45])=[O:15])=[C:20]([CH3:44])[CH:21]=2)=[C:5]([C:7]2[CH:6]=[CH:5][CH:4]=[C:3]([C:2]([F:13])([F:12])[F:1])[CH:8]=2)[CH:4]=1

Participants

3

Reactant 2

HCID 27343883-(Trifluoromethyl)phenylboronic acidHCID 57894211HCID 57894211, compound

Product 1

HCID 57894144HCID 57894144, compound

Procedure

The title compound is prepared according to Example 89 by using 3-trifluoromethylphenyl boronic acid and 3-{4-[3-(2-bromo-4-trifluoromethyl-phenoxy)-phenoxy]-2-methyl-phenyl}-propionic acid methyl ester to afford about 112 mg (63%). 1H NMR (400 MHz, CDCl3); MS (ES+) m/z mass calcd for C30H22O4F6 560, found 561 (M+1, 100%).

Workup

  1. customto afford about 112 mg (63%)

Sources & evidence

ORD record
ord-a93537692737408d8fcff2b05b6e4165
Source dataset
uspto-grants-2009_10
Patent number
US07608639B2

Reaction notes

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