(Pyrimidin-5-yl)boronic acid → HCID 57894129, compound

HRID 1822369Notes

Reaction equation

HRID 1822369 reaction equation
[N:1]1[CH:6]=[C:5](B(O)O)[CH:4]=[N:3][CH:2]=1.C([O:12][C:13](=[O:43])[CH2:14][CH2:15][C:16]1[CH:21]=[CH:20][C:19]([O:22][C:23]2[CH:28]=[C:27]([Cl:29])[CH:26]=[C:25]([O:30][C:31]3[CH:36]=[CH:35][C:34]([C:37]([F:40])([F:39])[F:38])=[CH:33][C:32]=3Br)[CH:24]=2)=[CH:18][C:17]=1[CH3:42])C>>[Cl:29][C:27]1[CH:28]=[C:23]([CH:24]=[C:25]([O:30][C:31]2[CH:32]=[CH:33][C:34]([C:37]([F:38])([F:39])[F:40])=[CH:35][C:36]=2[C:5]2[CH:6]=[N:1][CH:2]=[N:3][CH:4]=2)[CH:26]=1)[O:22][C:19]1[CH:20]=[CH:21][C:16]([CH2:15][CH2:14][C:13]([OH:43])=[O:12])=[C:17]([CH3:42])[CH:18]=1

Participants

3

Reactant 2

HCID 2795193(Pyrimidin-5-yl)boronic acidHCID 69079112HCID 69079112, compound

Product 1

HCID 57894129HCID 57894129, compound

Procedure

The title compound is prepared according to Example 89 by using pyrimidine-5-boronic acid and 3-{4-[3-(2-bromo-4-trifluoromethyl-phenoxy)-5-chloro-phenoxy]-2-methyl-phenyl}-propionic acid ethyl ester to afford about 31 mg (22%). 1H NMR (400 MHz, CDCl3); MS (ES+) m/z mass calcd for C27H20O4F3N2Cl 528, found 529 (M+1, 100%).

Workup

  1. customto afford about 31 mg (22%)

Sources & evidence

ORD record
ord-65f9b6c3c683469fa4a9e95a5a3315bf
Source dataset
uspto-grants-2009_10
Patent number
US07608639B2

Reaction notes

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