[1-(2-Hydroxy-indan-1-ylcarbamoyl)-2,2-dimethyl-propyl]-carbamic acid tert.butyl ester → HCID 68488353, compound

HRID 1822435Notes

Reaction equation

HRID 1822435 reaction equation
C(OC(=O)[NH:7][CH:8]([C:13](=[O:25])[NH:14][CH:15]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH2:17][CH:16]1[OH:24])[C:9]([CH3:12])([CH3:11])[CH3:10])(C)(C)C>C(Cl)Cl.C(O)(C(F)(F)F)=O>[NH2:7][CH:8]([C:9]([CH3:12])([CH3:11])[CH3:10])[C:13]([NH:14][CH:15]1[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[CH2:17][CH:16]1[OH:24])=[O:25]

Participants

3

Reactant 1

HCID 68488177[1-(2-Hydroxy-indan-1-ylcarbamoyl)-2,2-dimethyl-propyl]-carbamic acid tert.butyl ester

Product 1

HCID 68488353HCID 68488353, compound

Reagents, catalysts & solvents 1

HCID 21863450Trifluoroacetic acid methylene chlorideSolvent

Procedure

Compound 17 was kept in DCM-TFA 2:1 (2 mL) for 60 min at RT. The solution was cb-evaporated with toluene to dryness.

Workup

  1. customThe solution was cb-evaporated with toluene to dryness

Sources & evidence

ORD record
ord-1189590b4c42441596a19e5d824cecc0
Source dataset
uspto-grants-2009_10
Patent number
US07608590B2

Reaction notes

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