HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-beta-aminophenethyl alcohol → HCID 68492989, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-beta-aminophenethyl alcohol | HCID 2724025 | — |
| Reactant | 1-{[4-(7-Methoxy-2-phenyl-quinolin-4-yloxy)-pyrrolidine-2-carbonyl]-amino}-2-vinyl-cyclopropanecarboxylic acid ethyl ester | HCID 20765316 | — |
| Reactant | 1-{[1-[1-(2-Hydroxy-indan-1-ylcarbamoyl)-2,2-dimethyl-propylcarbamoyl]-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-pyrrolidine-2-carbonyl]-amino}-2-vinyl-cyclopropanecarboxylic acid ethyl ester | HCID 68491628 | — |
| Reactant | HCID 68493461 | HCID 68493461 | — |
| Product | HCID 68492989 | HCID 68492989 | — |
Reaction Steps
Compound 12 was treated as described for the preparation of 13 but with the use of (R)-2-phenylglycinol instead of 2-amino-N-(2-hydroxyindan-1-yl)-3,3-dimethyl butyramide instead of 2-amino-N-(2-hydroxy-indan-1-yl)-3,3-dimethyl-butyramide followed by ester hydrolysis as described for the preparation of compound 14 which gave the title compound. Purity by HPLC>95%. M+H+637.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07608590B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-45e8223cdf3d4dddb5dba8c285ccc5c7 |
| Source note | uspto-grants-2009_10 |