HRID1822446

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID5046859

未命名化合物

PRODUCTS

生成物

结构：C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H](Oc2cc(-c3ccccc3)nc3cc(OC)ccc23)CN1C(=O)N[C@@H](CCc1ccccc1)C(=O)N[C@H]1c2ccccc2C[C@H]1O)C(=O)O

HCID68496226

未命名化合物

PROCEDURE

实验过程

N-(tert.butoxycarbonyl)-L-phenethylglycine was attached to the resin as described for the preparation of compound 16 followed by reaction with (1S,2R)-cis-1-amino-2-indanol as described for the preparation of 17 and removal of the Boc group as described for 18. The afforded compound was then reacted with the chlorocarbamate achieved from 12 as described for the preparation of 13 which gave the title compound. Purity by HPLC>95%. M+H+810.4.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-a622cef8ac2448d49cdab7316a3f2ea5
来源数据集: uspto-grants-2009_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07608590B2
来源说明: uspto-grants-2009_10

反应 SMILES

C(OC(NC(C(C)(C)C)C(O)=O)=O)(C)(C)C.C1[C:25]2[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=2)[C@H](N)[C@@H]1O.C(O[C:33](=[O:53])[NH:34][CH:35]([C:40](=[O:52])[NH:41][CH:42]1[C:50]2[C:45](=[CH:46][CH:47]=[CH:48][CH:49]=2)[CH2:44][CH:43]1[OH:51])[C:36]([CH3:39])(C)C)(C)(C)C.ClNC(=O)[O-].C([O:61][C:62]([C:64]1([NH:69][C:70]([CH:72]2[CH2:76][CH:75]([O:77][C:78]3[C:87]4[C:82](=[CH:83][C:84]([O:88][CH3:89])=[CH:85][CH:86]=4)[N:81]=[C:80]([C:90]4[CH:95]=[CH:94][CH:93]=[CH:92][CH:91]=4)[CH:79]=3)[CH2:74][N:73]2C(=O)NC(C(=O)NC2C3C(=CC=CC=3)CC2O)C(C)(C)C)=[O:71])[CH2:66][CH:65]1[CH:67]=[CH2:68])=[O:63])C>>[OH:51][C@@H:43]1[CH2:44][C:45]2[C:50](=[CH:49][CH:48]=[CH:47][CH:46]=2)[C@@H:42]1[NH:41][C:40]([C@@H:35]([NH:34][C:33]([N:73]1[CH2:74][C@H:75]([O:77][C:78]2[C:87]3[C:82](=[CH:83][C:84]([O:88][CH3:89])=[CH:85][CH:86]=3)[N:81]=[C:80]([C:90]3[CH:95]=[CH:94][CH:93]=[CH:92][CH:91]=3)[CH:79]=2)[CH2:76][C@H:72]1[C:70]([NH:69][C@:64]1([C:62]([OH:63])=[O:61])[CH2:66][C@H:65]1[CH:67]=[CH2:68])=[O:71])=[O:53])[CH2:36][CH2:39][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[O:52]