HRID1822448

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID22035886

未命名化合物

结构：C=CC1CC1(NC(=O)C1CC(Oc2cc(-c3ccccc3)nc3cc(OC)ccc23)CN1C(=O)NC(C(=O)NC1c2ccccc2CC1O)C(C)(C)C)C(=O)OCC

HCID68491628

未命名化合物

PRODUCTS

生成物

结构：C=C[C@@H]1C[C@]1(NC(=O)[C@@H]1C[C@@H](Oc2cc(-c3ccccc3)nc3cc(OC)ccc23)CN1C(=O)N[C@H](C(=O)N[C@@H](CO)c1ccccc1)C(C)(C)C)C(=O)O

HCID68490859

未命名化合物

PROCEDURE

实验过程

The afforded compound was then reacted with the chlorocarbamate achieved from 12 as described for the preparation of 13 which gave the title compound. Purity by HPLC >95%. M+H+750.3.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-f9d0b3ad9e154fc6b944d47410aad734
来源数据集: uspto-grants-2009_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07608590B2
来源说明: uspto-grants-2009_10

反应 SMILES

ClNC(=O)[O-].C([O:8][C:9]([C:11]1([NH:16][C:17]([CH:19]2[CH2:23][CH:22]([O:24][C:25]3[C:34]4[C:29](=[CH:30][C:31]([O:35][CH3:36])=[CH:32][CH:33]=4)[N:28]=[C:27]([C:37]4[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=4)[CH:26]=3)[CH2:21][N:20]2[C:43](=[O:63])[NH:44][CH:45]([C:50](=[O:62])[NH:51][CH:52]2[C:60]3[C:55](=[CH:56][CH:57]=[CH:58][CH:59]=3)C[CH:53]2[OH:61])[C:46]([CH3:49])([CH3:48])[CH3:47])=[O:18])[CH2:13][CH:12]1[CH:14]=[CH2:15])=[O:10])C>>[OH:61][CH2:53][C@H:52]([NH:51][C:50]([C@@H:45]([NH:44][C:43]([N:20]1[CH2:21][C@H:22]([O:24][C:25]2[C:34]3[C:29](=[CH:30][C:31]([O:35][CH3:36])=[CH:32][CH:33]=3)[N:28]=[C:27]([C:37]3[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=3)[CH:26]=2)[CH2:23][C@H:19]1[C:17]([NH:16][C@:11]1([C:9]([OH:10])=[O:8])[CH2:13][C@H:12]1[CH:14]=[CH2:15])=[O:18])=[O:63])[C:46]([CH3:48])([CH3:49])[CH3:47])=[O:62])[C:60]1[CH:59]=[CH:58][CH:57]=[CH:56][CH:55]=1