HuagongsheHuagongshe Chemistry Print Report · For research reference only
Boc-L-Valine → HCID 57892953, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Boc-L-Valine | HCID 83693 | — |
| Reactant | 2-{[(Tert-butoxy)carbonyl]amino}-3,3-dimethylbutanoic acid | HCID 5046859 | — |
| Reactant | (1S,2R)-(-)-1-Amino-2-indanol | HCID 9866743 | — |
| Reactant | Chlorocarbamate | HCID 22035886 | — |
| Reactant | [1-(2-Hydroxy-indan-1-ylcarbamoyl)-2,2-dimethyl-propyl]-carbamic acid tert.butyl ester | HCID 68488177 | — |
| Reactant | 1-{[1-[1-(2-Hydroxy-indan-1-ylcarbamoyl)-2,2-dimethyl-propylcarbamoyl]-4-(7-methoxy-2-phenyl-quinolin-4-yloxy)-pyrrolidine-2-carbonyl]-amino}-2-vinyl-cyclopropanecarboxylic acid ethyl ester | HCID 68491628 | — |
| Product | HCID 57892953 | HCID 57892953 | 22% |
Reaction Steps
(2S)-tert-butoxycarbonylamino-3-methylbutyric acid was attached to the resin as described for the preparation of compound 16 followed by reaction with (1S,2R)-1-amino-2-indanol as described for the preparation of 17 and removal of the Boc group as described for 18. The afforded compound was then reacted with the chlorocarbamate achieved from 12 as described for the preparation of 13 which, after purification by HPLC, gave the title compound (10 mg, 22% yield), Purity by HPLC >90% M+H+748.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07608590B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-d634a92ba623435382397a91e701a9ea |
| Source note | uspto-grants-2009_10 |