HRID1822475

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID22082824

Ethyl 1-amino-2-ethenylcyclopropane-1-carboxylate

C8H13NO2

结构：COc1ccc2c(OC3CC(C(=O)O)N(C(=O)OC(C)(C)C)C3)cc(-c3csc(NC(C)C)n3)nc2c1

HCID74955511

未命名化合物

PRODUCTS

生成物

结构：C=CC1CC1(NC(=O)C1CC(Oc2cc(-c3csc(NC(C)C)n3)nc3cc(OC)ccc23)CN1C(=O)OC(C)(C)C)C(=O)OCC

HCID20773665

未命名化合物

收率 81%

PROCEDURE

实验过程

Compound 133 (300 mg, 0.56 mmol) was reacted with 1-amino-2-vinyl-cyclopropanecarboxylic acid ethyl ester (130 mg, 0.84 mmol) as described in Example 11 which gave the title compound (302 mg, 80%).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-292543d238294d2e8d0f78238bb199e1
来源数据集: uspto-grants-2009_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07608590B2
来源说明: uspto-grants-2009_10

反应 SMILES

[C:1]([O:5][C:6]([N:8]1[CH2:12][CH:11]([O:13][C:14]2[C:23]3[C:18](=[CH:19][C:20]([O:24][CH3:25])=[CH:21][CH:22]=3)[N:17]=[C:16]([C:26]3[N:27]=[C:28]([NH:31][CH:32]([CH3:34])[CH3:33])[S:29][CH:30]=3)[CH:15]=2)[CH2:10][CH:9]1[C:35]([OH:37])=O)=[O:7])([CH3:4])([CH3:3])[CH3:2].[CH2:38]([O:40][C:41]([C:43]1([NH2:48])[CH2:45][CH:44]1[CH:46]=[CH2:47])=[O:42])[CH3:39]>>[C:1]([O:5][C:6]([N:8]1[CH2:12][CH:11]([O:13][C:14]2[C:23]3[C:18](=[CH:19][C:20]([O:24][CH3:25])=[CH:21][CH:22]=3)[N:17]=[C:16]([C:26]3[N:27]=[C:28]([NH:31][CH:32]([CH3:33])[CH3:34])[S:29][CH:30]=3)[CH:15]=2)[CH2:10][CH:9]1[C:35](=[O:37])[NH:48][C:43]1([C:41]([O:40][CH2:38][CH3:39])=[O:42])[CH2:45][CH:44]1[CH:46]=[CH2:47])=[O:7])([CH3:4])([CH3:2])[CH3:3]