HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosgene → HCID 68490203, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosgene | HCID 6371 | — |
| Reactant | 1-{[4-(7-Methoxy-2-phenyl-quinolin-4-yloxy)-pyrrolidine-2-carbonyl]-amino}-2-vinyl-cyclopropanecarboxylic acid ethyl ester | HCID 20765316 | — |
| Reactant | HCID 77230248 | HCID 77230248 | — |
| Product | HCID 68490203 | HCID 68490203 | 86.8% |
Reaction Steps
Reaction of compound 12 (330 mg, 0.66 mmol), phosgene (1.6 ml, 1.9 M in toluene, 3 mmol) and hex-5-enylamine hydrochloride (500 mg, 3.68 mmol) following the procedure described in Example 120 gave the pure title product (328 mg, 80%), MS (M+H+) 627.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07608590B2 |
| Source dataset | uspto-grants-2009_10 |
| ORD ID | ord-aa20b0079f32415dae24dc66ed2e5ff9 |
| Source note | uspto-grants-2009_10 |