2-(4-Fluorophenyl)-2-oxoacetic Acid → HCID 15949982, compound

HRID 1822682Notes

Reaction equation

HRID 1822682 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:13]([C:14]3[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=3)=[CH:12][N:11]=[N:10][C:9]=2[NH:21][NH2:22])=[CH:4][CH:3]=1.[F:23][C:24]1[CH:29]=[CH:28][C:27]([C:30](=O)[C:31](O)=[O:32])=[CH:26][CH:25]=1>>[Cl:20][C:17]1[CH:18]=[CH:19][C:14]([C:13]2[CH:12]=[N:11][N:10]3[C:31](=[O:32])[C:30]([C:27]4[CH:28]=[CH:29][C:24]([F:23])=[CH:25][CH:26]=4)=[N:22][N:21]=[C:9]3[C:8]=2[C:5]2[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=2)=[CH:15][CH:16]=1

Participants

3

Reactant 2

HCID 5794402-(4-Fluorophenyl)-2-oxoacetic AcidHCID 22169696HCID 22169696, compound

Product 1

HCID 15949982HCID 15949982, compound

Procedure

The title compound was prepared using the method described in Example 1E, reacting 1-(4,5-bis(4-chlorophenyl)pyridazin-3-yl)hydrazine with 2-(4-fluorophenyl)-2-oxoacetic acid to give 8,9-bis(4-chlorophenyl)-3-(4-fluorophenyl)-4H -pyridazino[6,1-c][1,2,4]triazin-4-one. HPLC retention time=3.84 min; MS observed=463 (M+H); 1H NMR (CDCl3, 500 MHz) δ 8.76 (s, 1H), 8.58–8.53 (m, 2H), 7.39–7.34 (m, 4H), 7.31–7.25 (m, 2H), 7.22–7.13 (m, 4H).

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-3997fa9972444ac69fcd3810a5b74873
Source dataset
uspto-grants-2006_05
Patent number
US07037910B2

Reaction notes

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