反应详情

Prepared according to the procedure described for example 2 from 2-(2,6-difluoro-phenyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydro-pyrimidine-4-carboxylic acid ethyl ester (31 mg, 0.1 mmol) and 3,4-dimethylbenzylamine (68 mg, 0.5 mmol). The title product was obtained as an off-white solid (32.7 mg, 82% yield). 1HNMR (500 MHz, CDCl3) δ: 12.41 (1H, s), 7.74 (1H, br s), 7.51–7.45 (1H, m), 7.10–7.02 (5H, m), 4.51 (2H, d, J=6.10 Hz), 3.40 (3H, s), 2.24 (3H, s), 2.23(3H, s). HRMS (ESI) calcd for C21H20F2N3O3 (M+H): 400.1473; found: 400.01464.

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