Benzenemethanamine, 3,4-dimethyl- → HCID 54680194, compound

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Reaction Steps

Prepared according to the procedure described for example 2 from 2-(4-fluoro-2-methanesulfonyl-phenyl)-5-hydroxy-1-methyl-6-oxo-1,6-dihydro-pyrimidine-4-carboxylic acid ethyl ester (55.56 mg, 0.15 mmol) and 3,4-dimethylbenzylamine (102 mg, 0.75 mmol). The title product was obtained as a pink solid (59.8 mg, 87% yield). 1HNMR (500 MHz, CDCl3) δ: 12.25 (1H, s), 7.86 (1H, dd, J=7.63, 2.44 Hz), 7.49–7.44 (2H, m), 7.41 (1H, dd, J=8.54, 4.88 Hz), 7.07 (1H, d, J=7.63 Hz), 7.01 (1H, s), 6.97 (1H, d, J=7.63 Hz), 4.53 (1H, dd, J=14.65, 6.41 Hz), 4.43 (1H, dd, J=14.96, 5.49 Hz), 3.26 (3H, s), 3.01 (3H, s), 2.22 (6H, s). HRMS (ESI) calcd for C22H23FN3O5S (M+H): 460.1343; found: 460.1337.

Provenance & Evidence