Trifluoroacetic acid → HCID 9904040, compound

Participants

Reaction Steps

4-Nitroaniline (9.8 g), 6.5 ml of cyclopentadiene, and 5.5 ml of trifluoroacetic acid were dissolved in 70 ml of acetonitrile, and 10.0 g of hydroxypivalaldehyde was added at 0° C. After 30 minutes stirring at room temperature, the reaction mixture was concentrated under reduced pressure. The residue was purified by silica gel column chromatography (elution solvent: hexane:ethyl acetate=1:1) to obtain 4.8 g of the captioned compound. Its physical properties are shown below.

Provenance & Evidence