Isopropyl isocyanate → HCID 22170124, compound

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Reaction Steps

The compound of Example 49 (57 mg) was dissolved in 2 ml of dimethylformamide, and 0.03 ml of isopropyl isocyanate was added. After 30 minutes stirring at room temperature, the reaction mixture was diluted with water and ethyl acetate. The ethyl acetate layer was washed with water, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (elution solvent: hexane:ethyl acetate=1:1) to obtain 62 mg of the captioned compound. Its physical properties are shown below.

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