HCID 23568779, compound → HCID 22170120, compound

Participants

Reaction Conditions

Reaction Steps

The compound of Example 76 (134 mg) was dissolved in 15 ml of a mixed solution of methanol and tetrahydrofuran, and 15 ml of a 2 mol/l sodium hydroxide solution was added. After overnight stirring at 50° C., the reaction mixture was concentrated under reduced pressure. The resulting residue was acidified with saturated ammonium chloride solution and 2 mol/l hydrochloric acid solution, and then ethyl acetate was added. The ethyl acetate layer was washed with a saturated sodium chloride solution, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (elution solvents: hexane:ethyl acetate 4:1˜hexane:ethyl acetate=2:1˜hexane:ethyl acetate=1:1) to obtain 34 mg of the captioned compound. Its physical properties are shown below.

Provenance & Evidence