反应详情

A mixture of 3.59 g of ethyl 4-trimethylacetamido-3-pyridylpyruvate, 2.89 g of potassium hydroxide in 10 mL of ethanol and 40 mL of water is heated at reflux for 2 hours. At this time 3.1 g of acetophenone is added and refluxing is continued for 6 hours. The ethanol is removed in vacuo, the resulting aqueous solution is washed with ether and the aqueous layer is acidified to pH5. The product is collected washed with water and dried to afford (2-phenylpyridino[4,3-b]pyridin-4-yl) carboxylic acid as a white solid.

1. temperatureis heated
2. temperatureat reflux for 2 hours
3. temperaturerefluxing
4. customThe ethanol is removed in vacuo
5. washthe resulting aqueous solution is washed with ether
6. customThe product is collected
7. washwashed with water
8. customdried