4-Methylmorpholine → HCID 23568573, compound

Participants

Reaction Steps

One equivalent of isobutylchloroformate is added to a solution of N-Boc-L-norleucine and one equivalent of a base such as N-methylmorpholine in THF at 0□C. After two minutes, one equivalent of butylamine is added and the mixture allowed to warm to room temperature. After thirty minutes, the reaction mixture is passed through a bed of Celite and all volatiles are removed under reduced pressure to yield N-Boc-L-norleucine butylamide.

Provenance & Evidence