Triethylamine → HCID 178430861, compound

Participants

Reaction Steps

4-Methylimidazole (11.45 g, 140 mmol) was added in one portion to a solution of trichloropyrimidine in (2.47 g, 135 mmol) and triethylamine (30 mL, 216 mmol) in THF (500 mL). After 16 hrs, the reaction mixture was poured into saturated, aqueous ammonium chloride and extracted three times with ethyl acetate. The combined organic layers were washed with brine and dried over MgSO4. The reaction mixture was filtered and all volatiles were removed under reduced pressure. 2-(4-methylimidazolyl)-4,6-dichloropyrimidine was isolated by flash chromatography (15% ethyl acetate in hexane) as an off-white solid.

Provenance & Evidence