Ammonia → HCID 178506307, compound

Participants

Reaction Steps

Furanyl-imidazoles were prepared by the TosMIC reaction from aldehydes, which can be obtained either by reduction of acids, esters or amides; or by oxidation of primary alcohols. These procedures are well known in the literature. For example, ethyl 2-trifluoromethyl-furan-3-carboxylate (Scheme 17) prepared from literature procedures (U.S. Pat. No. 5,405,865, Apr. 11, 1995) was converted to an aldehyde by reduction of a Weinreb amide. The aldehyde was then reacted with the TosMIC and methanolic ammonia to yield 4-(2-trifluoromethyl-furan-3-yl)-imidazole.

Provenance & Evidence