Ethyl 3-oxohexanoate → HCID 135788280, compound

Participants

Reaction Steps

Quinoline-3-carboxamidine (314 mg), ethyl butyrylacetate (290 mg), and sodium ethoxide (21 wt % in ethanol, 1.1 mL) were refluxed for 48 h in 20 mL of ethanol. The solvent was evaporated and the residue was partitioned between ethyl acetate and brine. The ethyl acetate phase was dried with sodium sulfate and the solvent was evaporated. Silica gel chromatography (50:45:5 ethyl acetate/hexanes/methanol) provide 280 mg of 6-propyl-2-quinolin-3-yl-3H-pyrimidin-4-one.

Provenance & Evidence