HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 13561207, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Propargylamine | HCID 239041 | — |
| Reactant | 4-(((Tert-butoxy)carbonyl)amino)butanoic acid | HCID 294894 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 13561207 | HCID 13561207 | 28.2% |
Reaction Steps
To a mixture of 4-tert-butoxycarbonylaminobutyric acid (5 g), 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (5.66 g) and triethylamine (7.47 g) in dichloromethane (80 mL) at rt was added 2-propynylamine (1.49 g). After being stirred at rt for 3 h, the mixture was diluted with dichloromethane (80 mL) and washed with 0.5 M HCl (aqueous, 2×), saturated NaHCO)3 (1×) and water (1×). The dichloromethane was dried over sodium sulfate, filtered and evaporated to afford (3-Prop-2-ynylcarbamoyl-propyl)-carbamic acid tert-butyl ester (1.67 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07037916B2 |
| Source dataset | uspto-grants-2006_05 |
| ORD ID | ord-8cab12d2546a4ba5a95d4a32a8f057cb |
| Source note | uspto-grants-2006_05 |