HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1822828Generated: November 1, 2026
Diethyl (ethoxymethylene)malonate → Diethyl 2-(4-benzyloxy-3-methoxyanilino)methylenemalonate
https://huagongshe.com/reaction/1822828
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diethyl (ethoxymethylene)malonate | HCID 6871 | — |
| Reactant | 4-(Benzyloxy)-3-methoxyaniline | HCID 27226 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Diethyl 2-(4-benzyloxy-3-methoxyanilino)methylenemalonate | HCID 22170195 | 100.1% |
Reaction Steps
A mixture of 4-(Benzyloxy)-3-methoxyaniline (9.3 g, 40 mmol) and diethyl ethoxymethylenemalonate (9.65 g, 45 mmol) were heated at 120° C. for 1–1.5 h, the ethanol produced was removed under reduced pressure, affording 16 g (100% yield) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07037925B2 |
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| Source dataset | uspto-grants-2006_05 |
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| ORD ID | ord-88480e258e404b8b8deeef16f3ec8dde |
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| Source note | uspto-grants-2006_05 |
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