HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → Methyl 4-{[3-(aminocarbonyl)-6-methoxy-4-(2-toluidino)-7-quinolinyl]oxy}butanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Butanoic acid, 4-chloro-, methyl ester | HCID 76612 | — |
| Reactant | 7-Hydroxy-6-methoxy-4-(2-toluidino)-3-quinolinecarboxamide | HCID 135432926 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | Methyl 4-{[3-(aminocarbonyl)-6-methoxy-4-(2-toluidino)-7-quinolinyl]oxy}butanoate | HCID 10224117 | — |
Reaction Steps
A mixture of 7-hydroxy-6-methoxy-4-(2-toluidino)-3-quinolinecarboxamide (0.026 g, 0.080 mmol), DMSO (2.5 ml), K2CO3 (0.017 g, 0.12 mmol), and methyl 4-chlorobutanoate (0.011 g, 0.080 mmol) was refluxed for 2 h. The reactionmixture was filtered, evaporated and chromatographed on silica furnishing the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07037925B2 |
| Source dataset | uspto-grants-2006_05 |
| ORD ID | ord-8fb98255a31c4e2e8e09edc14a94e809 |
| Source note | uspto-grants-2006_05 |