HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1822843Generated: October 25, 2026
Acetic Acid → 4-(3-Aminocarbonyl-2-methylanilino)-6,7-dimethoxy-3-quinolinecarboxamide
https://huagongshe.com/reaction/1822843
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 3-Amino-2-methylbenzamide | HCID 16495773 | — |
| Reactant | 4-Chloro-6,7-dimethoxyquinoline-3-carboxamide | HCID 22170204 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-(3-Aminocarbonyl-2-methylanilino)-6,7-dimethoxy-3-quinolinecarboxamide | HCID 22170257 | 63.4% |
Reaction Steps
A mixture of 4-chloro-6,7-dimethoxy-3-quinolinecarboxamide (0.046 g, 0.17 mmol), 3-amino 2-metylbenzamide (0.036 g, 0.24 mmol) and acetic acid (40 μl) in DMF (0.8 ml) was heated at 100° C. for 18 h. After cooling the reaction mixture was diluted with water (20 ml) and made alkaline with 1 M NaOH. The precipitate was filtered of, rinsed with water and dried to give the title compound (41 mg, 61%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07037925B2 |
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| Source dataset | uspto-grants-2006_05 |
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| ORD ID | ord-0e0e4ca10d7b45ffa48a5b9c49223386 |
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| Source note | uspto-grants-2006_05 |
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