Acetic Acid → HCID 22170208, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-chloro-6,7-dimethoxy-3-quinolinecarboxamide (0.046 g, 0.17 mmol), 3-amino-2-methylbenzoic acid (0.035 g, 0.23 mmol) and acetic acid (40 μl) in DMSO (0.8 ml) was stirred at 100° C. for 5 h. After cooling the reaction mixture was washed several times with diethyl ether. The oily residue was dissolved in water and made alkaline with 1 M NaOH and then weakly acidified with acetic acid. The mixture was left at 5° C. over night and the resulting precipitate was collected by filtration, washed with water and dried to give the title compound (35 mg, 50%).

Provenance & Evidence