関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Acetic Acid | HCID 176 | — |
| 反応物 | Sodium Bicarbonate | HCID 516892 | — |
| 反応物 | 3-Methoxy-2-methylaniline | HCID 11804822 | — |
| 反応物 | 4-Chloro-6,7-dimethoxyquinoline-3-carboxamide | HCID 22170204 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 6,7-Dimethoxy-4-(3-methoxy-2-methylanilino)-3-quinolinecarboxamide | HCID 22170243 | 72% |
反応手順
A mixture of 4-chloro-6,7-dimethoxy-3-quinolinecarboxamide (0.046 g, 0.17 mmol), 3-methoxy-2-methylaniline (0.036 g, 0.26 mmol) and acetic acid (40 μl) in DMF (0.8 ml) was heated at 100° C. for 2.5 h. After cooling, the mixture was diluted with water (15 ml) and made alkaline with saturated NaHCO3. The resulting gummy precipitate was collected and crystallized from methanol-water to give the title compound (45 mg, 70%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07037925B2 |
|---|
| 出典データセット | uspto-grants-2006_05 |
|---|
| ORD ID | ord-cecbfc954e9c4795b263700ff40c03e4 |
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| 出典メモ | uspto-grants-2006_05 |
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