Acetic Acid → HCID 22170208, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-chloro-6,7-dimethoxy-3-quinolinecarboxamide (0.046 g, 0.17 mmol), 4-amino-2-methylbenzoic acid (0.036 g, 0.24 mmol) and acetic acid (40 μl) in DMF (0.8 ml) was heated at 100° C. for 12 h. After cooling, the mixture was diluted with water (15 ml) and made alkaline with saturated NaHCO3 and was then weakly acidified with acetic acid. The precipitate was filtered of and suspended in warm methanol. After cooling, the precipitate was filtered off and dried to give the title compound (31 mg, 47%).

Provenance & Evidence