HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluoro-2-methylaniline → 4-(4-Fluoro-2-methylanilino)-6-methoxy-3-quinolinecarboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluoro-2-methylaniline | HCID 67982 | — |
| Reactant | Acetic acid ethanol | HCID 18476134 | — |
| Reactant | 4-Chloro-6-methoxyquinoline-3-carboxamide | HCID 22170274 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-(4-Fluoro-2-methylanilino)-6-methoxy-3-quinolinecarboxamide | HCID 22170369 | — |
Reaction Steps
A mixture of 4-fluoro-2-methylaniline (0.025 mmol), 6-methoxy-4-chloro-3-quinolinecarboxamide (0.025 mmol), 50 μl 20% Acetic acid/Ethanol and 250 μl ethanol was refluxed for four hours. After cooling to room temperature the solvent was removed in vacuu.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07037925B2 |
| Source dataset | uspto-grants-2006_05 |
| ORD ID | ord-101c64c03e9c44128660c91cd299617e |
| Source note | uspto-grants-2006_05 |