HuagongsheHuagongshe Chemistry Print Report · For research reference only
(2-Methyl-3-nitrophenyl)acetonitrile → 3-Amino-2-methylphenylacetonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (2-Methyl-3-nitrophenyl)acetonitrile | HCID 13530896 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol ethylacetate | HCID 21584252 | — |
| Product | 3-Amino-2-methylphenylacetonitrile | HCID 22170320 | 77% |
Reaction Steps
2-(2-Methyl-3-nitrophenyl)acetonitrile (Askam, V. et al. J. Chem. Soc. C (1969)1935–1936;) was hydrogenated over 5% palladium-charcoal 50 mg in EtOAc/EtOH 1:1 (14 ml) for three hours. The mixture was filtered through celite, and the filtrate was concentrated to give the title compound 77 mg (77%) as a white powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07037925B2 |
| Source dataset | uspto-grants-2006_05 |
| ORD ID | ord-c40df85708654243af8e209485f6c66e |
| Source note | uspto-grants-2006_05 |