Triethylamine → HCID 22170496, compound

Participants

Reaction Steps

Ethyl malonyl chloride (0.88 ml; 6.99 mmol) was added to a mixture of 2-amino-5-bromothiazole hydrobromide (1.30 g; 5.00 mmol) and Et3N (2.08 ml; 14.94 mmol) in THF (6 ml) at 0–5° C. The mixture was stirred at room temperature overnight, then the reaction was quenched with potassium sarcosinate (0.25 g; 2.00 mmol) and water (12 ml). The product was isolated by filtration as a white solid (0.75 g, 51%): m.p. 165–166° C.

Provenance & Evidence