Triethylamine → HCID 22170552, compound

Participants

Reaction Steps

To a mixture of 4-sulfamoylbenzoic acid (1.0 g, 4.97 mmol), Et3N (1.5 ml, 10.78 mmol), DMF (5 ml) and THF (5 ml) isobutyl choroformate (0.70 ml, 5.36 mmol) was added dropwise at −10° C. After stirring for 1 h, a solution of 2-amino-5-bromothiazole hydrobromide (1,55 g, 5.96=mol) and Et3N (0.83 ml, 5.96 mmol) in DMF (6 ml) and THF (4 ml) was added dropwise to the mixture at the same temperature.

Provenance & Evidence