反应详情

温度

0 °C

2 g (10.57 mmol) of 3-indolepropionic acid were dissolved in 50 ml of methanol. The solution was cooled to 0° C. and 5 ml of sulfuric acid 96% were dropped under stirring. The solution was maintained at room temperature overnight and then poured onto ice-water, basified with 30% ammonium hydrate and finally extracted with methylene chloride. The organic layer was dried over anhydrous sodium sulfate and evaporated to dryness to give 2.3 g of an oily product (93% yield).

1. temperatureThe solution was maintained at room temperature overnight
2. additionpoured onto ice-water
3. extractionfinally extracted with methylene chloride
4. dry with materialThe organic layer was dried over anhydrous sodium sulfate
5. customevaporated to dryness