反应详情

To a suspension of resin N-Cyclohexylcarbodiimide N′-methylpolystyrene (0.251 g, 2.39 mmol g, 0.6 mmol), previously washed with DCM (3×5 ml), in DCM (4 ml) at room temperature, 2-bromophenylacetic acid (0.086 g, 0.4 mmol) was added. After 10 min., a solution of 2-amino-5-isopropyl-1,3-thiazole (0.0284 g, 0.2 mmol) in DCM (4 ml) was added. The mixture was shaked for 24 hours at room temperature, the resin filtered and washed with DCM (3×10 ml). The filtrated were combined, washed with water, 5% HCl, water, saturated sodium bicarbonate and water, dried over sodium sulfate and evaporated.

1. washpreviously washed with DCM (3×5 ml), in DCM (4 ml) at room temperature
2. waitThe mixture was shaked for 24 hours at room temperature
3. filtrationthe resin filtered
4. washwashed with DCM (3×10 ml)
5. washwashed with water, 5% HCl, water, saturated sodium bicarbonate and water
6. dry with materialdried over sodium sulfate
7. customevaporated