反应详情

To a suspension of N-(4-hydroxy-2,5-dimethyl-phenyl)-acetamide (8.0 g, 44.6 mmol) and 4-(2-chloro-ethyl)-morpholine hydochloride (9.97 g, 53.6 mmol) in 50 mL of dioxane was added a solution of NaOH (4.29 g in 50 mL of water). The mixture was refluxed for 2 h and evaporated to dryness under reduced pressure. The residue was dissolved in CH2Cl2 and washed with 0.5 N NaOH. The organic phase was dried (Na2SO4), evaporated, and crystallized from CH2Cl2-hexane to give N-[2,5-dimethyl-4-(2-morpholin-4-yl-ethoxy)-phenyl]-acetamide as gray solid (11.6 g, 89%).

1. temperatureThe mixture was refluxed for 2 h
2. customevaporated to dryness under reduced pressure
3. dissolutionThe residue was dissolved in CH2Cl2
4. washwashed with 0.5 N NaOH
5. dry with materialThe organic phase was dried (Na2SO4)
6. customevaporated
7. customcrystallized from CH2Cl2-hexane