Chloral Hydrate → HCID 73867562, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of chloral hydrate (910 mg, 5.5 mmol) in 12 mL of water were added, in order: 13 g of anhydrous Na2SO4; a solution of 2,5-dimethyl-4-(2-morpholin-4-yl-ethoxy)-pheylamine hydrogen chloride (1.61 g, 5 mmol) in water (3 mL); and finally, a solution of hydroxylamine hydrochloride (1.12 g, 16 mmol) in 5 mL of water. The mixture was heated in an oil bath (130° C.) with stirring for 15 min, then cooled down to room temperature, diluted with water, neutralized to pH 7 with concentrate aq. NaHCO3, and extracted with EtOAc. The combined organic layer was was washed with water, dried (Na2SO4) and concentrated under reduced pressure to give N-[2,5-dimethyl-4-(2-morpholin-4-yl-ethoxy)-phenyl]-2-hydroxyimino-acetamide as yellow solid (1.45 g, 91%).

Provenance & Evidence