HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1822908Generated: October 31, 2026
5-[(4-Fluorophenyl)methyl]-4H-1,2,4-triazole-3,4-diamine → 5-Chloro-3-(4-fluoro-benzyl)-9H-1,2,3a,4,9,10-hexaaza-cyclopenta[b]fluoren-6-ol
https://huagongshe.com/reaction/1822908
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 5-[(4-Fluorophenyl)methyl]-4H-1,2,4-triazole-3,4-diamine | HCID 21919322 | — |
| Reactant | 4-chloro-5-hydroxy-1H-indole-2,3-dione | HCID 22169664 | — |
| Solvent | Ethylene Glycol | HCID 174 | — |
| Product | 5-Chloro-3-(4-fluoro-benzyl)-9H-1,2,3a,4,9,10-hexaaza-cyclopenta[b]fluoren-6-ol | HCID 135502690 | — |
Reaction Steps
According to a cyclization procedure for Example 30, 0.60 mmol of 4-chloro-5-hydroxy-1H-indole-2,3-dione (118.5 mg) and 0.70 mmol of (4-fluoro-benzyl)-[1,2,4]triazole-3,4-diamine (145 mg) in 2 mL of ethylene glycol was stirred at 125° C. overnight (16 hr).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07037909B2 |
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| Source dataset | uspto-grants-2006_05 |
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| ORD ID | ord-c6138ec3d0b34960abf1beb7d25097e7 |
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| Source note | uspto-grants-2006_05 |
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