HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1822909Generated: October 30, 2026
4-[(4,5-Diamino-4H-1,2,4-triazol-3-yl)methyl]phenol → 5-Chloro-3-(4-hydroxy-benzyl)-9H-1,2,3a,4,9,10-hexaaza-cyclopenta[b]fluoren-6-ol
https://huagongshe.com/reaction/1822909
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 4-[(4,5-Diamino-4H-1,2,4-triazol-3-yl)methyl]phenol | HCID 21919313 | — |
| Reactant | 4-chloro-5-hydroxy-1H-indole-2,3-dione | HCID 22169664 | — |
| Solvent | Ethylene Glycol | HCID 174 | — |
| Product | 5-Chloro-3-(4-hydroxy-benzyl)-9H-1,2,3a,4,9,10-hexaaza-cyclopenta[b]fluoren-6-ol | HCID 135457846 | — |
Reaction Steps
According to a cyclization procedure for Example 30, 0.60 mmol of 4-chloro-5-hydroxy-1H-indole-2,3-dione (118.5 mg) and 0.70 mmol of 4-(4,5-diamino-4H-[1,2,4]triazol-3-ylmethyl)-phenol (144 mg) in 2 mL of ethylene glycol was stirred at 125° C. overnight (16 hr).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07037909B2 |
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| Source dataset | uspto-grants-2006_05 |
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| ORD ID | ord-df82bac2a79840c5b385edefbf7ce618 |
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| Source note | uspto-grants-2006_05 |
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