化工社化工社 化学情報印刷レポート · 研究参考用
1-(Bromomethyl)-2,3,4-trifluorobenzene → Methylamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-(Bromomethyl)-2,3,4-trifluorobenzene | HCID 2777050 | — |
| 反応物 | Methyl 1-(4-hydroxyphenyl)-5-oxopyrrolidine-3-carboxylate | HCID 2883518 | — |
| 反応物 | (RS)-5-oxo-1-[4-(2,3,4-trifluoro-benzyloxy)-phenyl]-pyrrolidine-3-carboxylic acid methyl ester | HCID 68614811 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | Methylamine | HCID 6329 | — |
| 生成物 | (RS)-5-oxo-1-[4-(2,3,4-trifluoro-benzyloxy)-phenyl]-pyrrolidine-3-carboxylic acid methylamide | HCID 9999690 | — |
反応手順
The title compound is prepared by alkylation of the (RS)-1-(4-hydroxyphenyl)-5-oxo-pyrrolidine-3-carboxylic acid methyl ester with 2,3,4-trifluorobenzyl bromide giving the (RS)-5-oxo-1-[4-(2,3,4-trifluoro-benzyloxy)-phenyl]-pyrrolidine-3-carboxylic acid methyl ester as a white solid (94% of theory) which, thereupon, by treatment with methylamine in ethanol at 50° C. yields the (RS)-5-oxo-1-[4-(2,3,4-trifluoro-benzyloxy)-phenyl]-pyrrolidine-3-carboxylic acid methylamide. Yield: 99% of theory as a white solid; MS: m/e=379 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07037935B2 |
| 出典データセット | uspto-grants-2006_05 |
| ORD ID | ord-750c848bf65748c5849522cfe57e39ad |
| 出典メモ | uspto-grants-2006_05 |