Potassium Carbonate → HCID 69781444, compound

Participants

Reaction Steps

In analogy to the alkylation described in Example 1d), the (RS)-1-(4-hydroxy-3-methyl-phenyl)-5-oxo-pyrrolidine-3-carboxylic acid methyl ester is reacted with 3-fluorobenzyl bromide in presence of potassium carbonate in DMF at 80° C. to yield the (RS)-1-[(4-(3-fluoro-benzyloxy)-3-methyl-phenyl)-5-oxo-pyrrolidine-3-carboxylic acid methyl ester as a light brown oil; MS: m/e=375 (M+NH4)+.

Provenance & Evidence